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- Murakami, Y., Obuchi, M., Kamizawa, H., Miyazaki, S., Kishimura, A., Oketani, R., Hiramatsu, K., Leproux, P., Hayashi, Y., Shiraki, K., & Kano, H. (2025). Exploring liquid–liquid phase separation in vitro and in vivo using multimodal nonlinear optical imaging. Analytical Sciences DOI: 10.1007/s44211-025-00747-3
- Mitsuaki Kashiwagi, Goichi Beck, Mika Kanuka, Yoshifumi Arai, Kaeko Tanaka, Chika Tatsuzawa, Yumiko Koga, Yuki C. Saito, Marina Takagi, Yo Oishi, Masanori Sakaguchi, Kousuke Baba, Masashi Ikuno, Hodaka Yamakado, Ryosuke Takahashi, Masashi Yanagisawa, Shigeo Murayama, Takeshi Sakurai, Kazuya Sakai, Yoshimi Nakagawa, Masahiko Watanabe, Hideki Mochizuki, Yu Hayashi.
A pontine-medullary loop crucial for REM sleep and its deficit in Parkinson’s disease.
Cell 187(22):6272 (2024). DOI:10.1016/j.cell.2024.08.046
- Takaya Suganuma, Sena Hatori, Chung-Kuan Chen, Satoshi Hori, Mika Kanuka, Chih-Yao Liu, Chika Tatsuzawa, Masashi Yanagisawa, Yu Hayashi.
Caffeoylquinic Acid Mitigates Neuronal Loss and Cognitive Decline in 5XFAD Mice Without Reducing the Amyloid-β Plaque Burden.
Journal of Alzheimer’s disease 99(4):1285-1301 (2024) DOI: 10.3233/JAD-240033.
- 坂口義彦, 林悠
アデノシンと睡眠
老年精神医学雑誌 35, 237-243 (2024)
- Ayaka Nakai, Mitsuaki Kashiwagi, Tomoyuki Fujiyama, Kanako Iwasaki, Arisa Hirano, Hiromasa Funato, Masashi Yanagisawa, Takeshi Sakurai, Yu Hayashi.
Crucial role of TFAP2B in the nervous system for regulating NREM sleep.
Molecular Brain 17(1):13 (2024). DOI:10.1186/s13041-024-01084-8
- Masami Arai, Etsuko Suzuki, Satoshi Kitamura, Momoyo Otaki, Kaori Kanai, Miwako Yamasaki, Masahiko Watanabe, Yuki Kambe, Koshi Murata, Yuuki Takada, Tetsu Arisawa, Kenta Kobayashi, Rei Tajika, Tomoyuki Miyazaki, Masahiro Yamaguchi, Michael Lazarus, Yu Hayashi, Shigeyoshi Itohara, Alban de Kerchove d’Exaerde, Hiroyuki Nawa, Ryang Kim, Haruhiko Bito, Toshihiko Momiyama, Daiki Masukawa, Yoshio Goshima.
Enhancement of Haloperidol-Induced Catalepsy by GPR143, an L-Dopa Receptor, in Striatal Cholinergic Interneurons.
The Journal of Neuroscience 44(11):e1504232024 (2024) DOI: 10.1523/JNEUROSCI.1504-23.2024
- 林直子, 林悠
睡眠の基礎研究
睡眠医療（ライフ・サイエンス）Vol.17 (4), pp439-443 (2023)
- 林直子, 林悠
Q&A－神経科学の素朴な疑問 眠れないと認知症になるのは本当ですか？
Neuroscience（中外医学社）Vol.41 (6), pp870 (2023)
- 田中拳斗, 柏木光昭, 林悠
睡眠の進化ー脊椎動物の多様な睡眠のあり方とそれを支える神経機構の進化についてー
Clinical Neuroscience（中外医学社）41 (12), 1599-1604 (2023).
- Shinichi Miyazaki, Yusuke Murakami, Sakiko Honjoh, Yu Hayashi, Hideki Kano
Coherent Anti-Stokes Raman Scattering (CARS) Microscopy and its Applications in Life Sciences
Raman Spectroscopy in Human Health and Biomedicine (2023) Chapter 9, pp299-336
- 岡部雄斗, 林直子, 稲富宏之, 林悠
睡眠の科学-睡眠研究の最前線とリハビリテーションへの応用の可能性-
理学療法ジャーナル（医学書院）Vol.57 (8), pp900-907 (2023)
- Anastasios Koutsoumparis, Inka Busack, Chung-Kuan Chen, Yu Hayashi, Bart P Braeckman, David Meierhofer, Henrik Bringmann.
Reverse genetic screening during L1 arrest reveals a role of the diacylglycerol kinase 1 gene dgk-1 and sphingolipid metabolism genes in sleep regulation.
Genetics (2023) DOI: 10.1093/genetics/iyad124.
- Chung-Kuan Chen, Taizo Kawano, Masashi Yanagisawa, Yu Hayashi.
Forward genetic screen of Caenorhabditis elegans mutants with impaired sleep reveals a crucial role of neuronal diacylglycerol kinase DGK-1 in regulating sleep.
Genetics 225(2) (2023) DOI: 10.1093/genetics/iyad140.
- Shinnosuke Yasugaki, Hibiki Okamura, Ami Kaneko, Yu Hayashi.
Bidirectional relationship between sleep and depression.
Neuroscience Research DOI: 10.1016/j.neures.2023.04.006 (2023).
- Taizo Kawano, Mitsuaki Kashiwagi, Mika Kanuka, Chung-Kuan Chen, Shinnosuke Yasugaki, Sena Hatori, Shinichi Miyazaki, Kaeko Tanaka, Hidetoshi Fujita, Toshiro Nakajima, Masashi Yanagisawa, Yoshimi Nakagawa, Yu Hayashi.
ER proteostasis regulators cell-non-autonomously control sleep.
Cell Reports 42(3):112267 (2023). DOI:10.1016/j.celrep.2023.112267
- Staci J. Kim, Noriko Hotta-Hirashima, Fuyuki Asano, Tomohiro Kitazono, Kanako Iwasaki, Shinya Nakata, Haruna Komiya, Nodoka Asama, Taeko Matsuoka, Tomoyuki Fujiyama, Aya Ikkyu, Miyo Kakizaki, Satomi Kanno, Jinhwan Choi, Deependra Kumar, Takumi Tsukamoto, Asmaa Elhosainy, Seiya Mizuno, Shinichi Miyazaki, Yousuke Tsuneoka, Fumihiro Sugiyama, Satoru Takahashi, Yu Hayashi, Masafumi Muratani, Qinghua Liu, Chika Miyoshi, Masashi Yanagisawa & Hiromasa Funato.
Kinase signalling in excitatory neurons regulates sleep quantity and depth.
Nature 612(7940):512-518 (2022) DOI: 10.1038/s41586-022-05450-1
- Iyo Koyanagi, Taro Tezuka, Jiahui Yu, Sakthivel Srinivasan, Toshie Naoi, Shinnosuke Yasugaki, Ayaka Nakai, Shimpei Taniguchi, Yu Hayashi, Yasushi Nakano, Masanori Sakaguchi.
Fully automatic REM sleep stage-specific intervention systems using single EEG in mice.
Neuroscience Research 186:51 (2022) DOI: 10.1016/j.neures.2022.10.001
- Shinya Okuda, Takeo Nakayama, Norihito Uemura, Rie Hikawa, Masashi Ikuno, Hodaka Yamakado, Haruhisa Inoue, Naoko Tachibana, Yu Hayashi, Ryosuke Takahashi, Naohiro Egawa
Striatal-inoculation of α-synuclein preformed fibrils aggravated the phenotypes of REM sleep without atonia in A53T BAC-SNCA transgenic mice.
International Journal of Molecular Sciences 23(21):13390 (2022)
DOI: 10.3390/ijms232113390.
- 荒井佳史、柏木光昭、林悠
レム睡眠: その制御回路および疾患との関連
実験医学2022年7月号Vol.40 No.11 (2022)
- 岡村 響, 安垣 進之助, 金子 杏美, 林 悠
うつ病と睡眠障害の関係性に関する研究の最前線
精神科Resident（先端医学社）Vol.3 (3), pp75-79 (2022)
- 金子 杏美, 安垣 進之助, 林 悠
多様な動物の眠りから考える睡眠の多様性と普遍性
学会誌「実験動物ニュース」（実験動物学会）, Vol.71 (3), pp125-129 (2022)
- Shinichi Miyazaki, Taizo Kawano, Masashi Yanagisawa, Yu Hayashi.
Intracellular Ca2+ dynamics in the ALA neuron reflect sleep pressure and regulate sleep in Caenorhabditis elegans.
iScience 25(6):104452 (2022) DOI:10.1016/j.isci.2022.104452
- 羽鳥 聖七, 宮崎 慎一, 林 悠
Two process model
睡眠医療 16: 79-84 (2022)
- 蔡佳容, 菅沼 貴也, 林 悠
レム睡眠中の大脳血流量の大幅な上昇の直接的な証拠――睡眠中の脳のリフレッシュ機構の解明に向けて
医学のあゆみ（医歯薬出版株式会社）281巻7号 776-777 (2022)
- Fangzhou Li, Shoya Matsumori, Naohiro Egawa, Shusuke Yoshimoto, Kotaro Yamashiro, Haruo Mizutani, Noriko Uchida, Atsuko Kokuryu, Akira Kuzuya, Ryosuke Kojima, Yu Hayashi, Ryosuke Takahashi.
Predictive diagnostic approach to dementia and dementia subtypes using wireless and mobile electroencephalography-A pilot study.
Bioelectricity Mar 2022.3-11. doi.org/10.1089/bioe.2021.0030
- Yusuke Murakami, Minori Masaki, Shinichi Miyazaki, Ryosuke Oketani, Yu Hayashi, Masashi Yanagisawa, Sakiko Honjoh, and Hideaki Kano.
Spectroscopic second and third harmonic generation microscopy using a femtosecond laser source in the third near-infrared (NIR-III) optical window.
Biomedical Optics Express 13(2), 694-708(2022)
- Hibiki Okamura, Shinnosuke Yasugaki, Haruka Suzuki-Abe, Yoshifumi Arai, Katsuyasu Sakurai, Masashi Yanagisawa, Hotaka Takizawa, and Yu Hayashi.
Long-term effects of repeated social defeat stress on brain activity during social interaction in BALB/c mice.
eNeuro 9(3) (2022) DOI:10.1523/ENEURO.0068-22.
- Shinnosuke Yasugaki, Yu Hayashi, Michael Lazarus.
NREM-REM sleep reguration.
Reference Module in Neuroscience and Biobehavioral Psychology DOI: 10.1016/B978-0-12-822963-7.00229-2 (2021)
- Chih-Yao Liu, 安垣 進之助, 林 悠
環境変化やストレスに対するレム睡眠調節機構の一端の解明
Neuroscience News 2021.No.4:26-28(2021)
- 和泉 賢明、林 直子、高橋 良輔、林 悠
睡眠・覚醒の調節機構：その謎から臨床へ
睡眠の進化：無脊椎動物から脊椎動物に至る多様な生物の眠りから考える
Progress in Medicine Vol.41 No.12:50-55 (2021)
- Mitsuaki Kashiwagi, Mika Kanuka, Kaeko Tanaka, Masayo Fujita, Ayaka Nakai, Chika Tatsuzawa, Kazuto Kobayashi, Kazutaka Ikeda, Yu Hayashi.
Impaired wakefulness and rapid eye movement sleep in dopamine-deficient mice.
Molecular Brain 14:170 (2021) DOI: 10.1186/s13041-021-00879-3
- Chia-Jung Tsai, Takeshi Nagata, Chih-Yao Liu, Takaya Suganuma, Takeshi Kanda, Takehiro Miyazaki, Kai Liu, Tsuyoshi Saitoh, Hiroshi Nagase, Michael Lazarus, Kaspar Vogt, Masashi Yanagisawa, Yu Hayashi.
Cerebral capillary blood flow upsurge during REM sleep is mediated by A2A receptors.
Cell Reports 17:109558 (2021).
- Ayaka Nakai, Tomoyuki Fujiyama, Nanae Nagata, Mitsuaki Kashiwagi, Aya Ikkyu, Marina Takagi, Chika Tatsuzawa, Kaeko Tanaka, Miyo Kakizaki, Mika Kanuka, Taizo Kawano, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Takeshi Sakurai, Masashi Yanagisawa, Yu Hayashi.
Sleep Architecture in Mice Is Shaped by the Transcription Factor AP-2β.
Genetics 216:753-764 (2020) DOI: 10.1534/genetics.120.303435
*Selected for the 2020 Spotlight collection of research and scholarship excellence published in the GSA journals
- Risa Yamazaki, Hirofumi Toda, Paul-Antoine Libourel, Yu Hayashi, Kaspar E Vogt, and Takeshi Sakurai.
Evolutionary Origin of Distinct NREM and REM Sleep.
Frontiers in Psychology 11:567618 (2020).
- Michael Lazarus, Yu Hayashi, Sakiko Honjoh, Kaspar E Vogt, Ada Eban-Rothschild, Qinghua Liu, and Takeshi Sakurai.
Editorial: The Gating and Maintenance of Sleep and Wake: New Circuits and Insights.
Frontiers in Neuroscience 14:773 (2020).
- Shinichi Miyazaki, Philippe Leproux, Vincent Couderc, Yu Hayashi, Hideaki Kano.
Multimodal nonlinear optical imaging of Caenorhabditis elegans with multiplex coherent anti-Stokes Raman scattering, third-harmonic generation, second-harmonic generation, and two-photon excitation fluorescence.
Applied Physics Express 13:072002-1-5 (2020).
- Mitsuaki Kashiwagi and Yu Hayashi.
The existence of two states of sleep as a common trait in various animals and its molecular and neuronal mechanisms.
Current Opinion in Physiology 15: 197-202 (2020) DOI: 10.1016/j.cophys.2020.03.007
- Chih-Yao Liu, Chia-Jung Tsai, Shinnosuke Yasugaki, Nanae Nagata, Miho Morita, Ayako Isotani, Masashi Yanagisawa and Yu Hayashi.
Copine-7 is required for REM sleep regulation following cage change or water immersion and restraint stress in mice.
Neuroscience Research 165:14-25 (2020) DOI: 10.1016/j.neures.2020.04.002
- Sakura Eri B. Maezono (*Co-first author), Mika Kanuka (*Co-first author), Chika Tatsuzawa, Miho Morita, Taizo Kawano, Mitsuaki Kashiwagi, Pimpimon Nondhalee, Masanori Sakaguchi, Takashi Saito, Takaomi C. Saido, Yu Hayashi.
Progressive changes in sleep and its relations to amyloid-β distribution and learning in single App knock-in mice.
eNeuro 7(2) (2020) DOI: 10.1523/ENEURO.0093-20.2020
- Chia-Jung Tsai, Chih-Yao Liu, Michael Lazarus, Yu Hayashi.
Sleep architecture of adenosine A2A receptor-deficient mice.
Sleep and Biological Rhythms 18:275-279 (2020) DOI: 10.1007/s41105-020-00260-2
- Mitsuaki Kashiwagi, Mika Kanuka, Chika Tatsuzawa, Hitomi Suzuki, Miho Morita, Kaeko Tanaka, Taizo Kawano, Jay W Shin, Harukazu Suzuki, Shigeyoshi Itohara, Masashi Yanagisawa, Yu Hayashi.
Widely Distributed Neurotensinergic Neurons in the Brainstem Regulate NREM Sleep in Mice.
Current Biology 30:1002 (2020) DOI:10.1016/j.cub.2020.01.047
- 安垣 進之助, 林 悠.
睡眠学 第2版（朝倉書店）.
第1部「睡眠科学」第1章「睡眠の動態」（2020).
- Shinnosuke Yasugaki, Chih-Yao Liu, Mitsuaki Kashiwagi, Mika Kanuka, Takato Honda, Shingo Miyata, Masashi Yanagisawa, Yu Hayashi.
Effects of 3 Weeks of Water Immersion and Restraint Stress on Sleep in Mice.
Frontiers in Neuroscience 13:1072 (2019) DOI: 10.3389/fnins.2019.01072
- 高木 眞莉奈, 林 悠.
睡眠の意義 －神経変性疾患の観点から－.
実験医学（羊土社）37 (6), 889-893 (2018).
- 安垣 進之助, 林 悠.
ニューロサイエンスの最新情報 －レム睡眠は何のためにあるのか－.
Clinical Neuroscience（中外医学社）37 (3), 358-359 (2018).
- 中井 彩加, 林 悠.
睡眠の役割の研究の最前線 －記憶学習・老廃物の除去・デルタ波－.
Clinical Neuroscience（中外医学社）37 (1), 33-36 (2018).
- Mitsuaki Kashiwagi and Yu Hayashi.
Life Without Dreams: Muscarinic Receptors Are Required to Regulate REM Sleep in Mice.
Cell Reports 24, 2211-2212 (2018).
- 大石 陽, 林 悠, 柳沢 正史.
睡眠の制御メカニズムとその破綻に伴う行動異常.
実験医学増刊「脳神経回路と高次脳機能 スクラップ＆ビルドによる心の発達と脳疾患の謎を解く」（羊土社）36 (12) (2018).
- Shinichi Miyazaki, Chih-Yao Liu, and Yu Hayashi.
Sleep in vertebrate and invertebrate animals, and insights into the function and evolution of sleep.
Neuroscience Research 118, 3-12 (2017).
- Yu Hayashi and Shigeyoshi Itohara.
Cutting-edge approaches to unwrapping the mysteries of sleep.
Neuroscience Research 118, 1-2 (2017).
- Yasuda, K., Hayashi, Y., Yoshida, T., Kashiwagi, M., Nakagawa, N., Michikawa, T., Tanaka, M., Ando, R., Huang, A., Hosoya, T., McHugh, T.J., Kuwahara, M., Itohara, S.
Schizophrenia-like phenotypes in mice with NMDA receptor ablation in intralaminar thalamic nucleus cells and gene therapy-based reversal in adults.
Translational Psychiatry 7, e1047 (2017).
- Yu Hayashi and Chih-Yao Liu.
Brain Evolution by Design: From Neural Origin to Cognitive Architecture. Springer; 1st ed. Chapter 15. The Evolution and Function of Sleep (2017).
- 髙木 眞莉奈, 林 悠.
レム睡眠の神経基盤、生理的意義および進化.
医学のあゆみ（医歯薬出版株式会社）263 (9), 740-746 (2017).
- 髙木 眞莉奈, 林 悠.
レム睡眠のメカニズムと生理的意義.
生化学（日本生化学学会）89 (6) 911-916 (2017).
- Yasuhiro Ogawa, Yoko Irukayama-Tomobe, Nobuyuki Murakoshi, Maiko Kiyama, Yui Ishikawa, Naoto Hosokawa, Hiromu Tominaga, Shuntaro Uchida, Saki Kimura, Mika Kanuka, Miho Morita, Michito Hamada, Satoru Takahashi, Yu Hayashi, Masashi Yanagisawa.
Peripherally administered orexin improves survival of mice with endotoxin shock.
eLife 2016; 5: e21055 (2016).
- Mitsuaki Kashiwagi and Yu Hayashi.
The Function of REM Sleep: Implications from Transgenic Mouse Models.
Brain Nerve 68, 1205-1211 (2016).
- Hiromasa Funato, Chika Miyoshi (*Co-second author), Tomoyuki Fujiyama (*Co-second author), Takeshi Kanda (*Co-second author), Makito Sato (*Co-second author), Zhiqiang Wang, Jing Ma, Shin Nakane, Jun Tomita, Aya Ikkyu, Miyo Kakizaki, Noriko Hotta-Hirashima,Satomi Kanno, Haruna Komiya, Fuyuki Asano, Takato Honda, Staci J. Kim, Kanako Harano, Hiroki Muramoto, Toshiya Yonezawa, Seiya Mizuno, Shinichi Miyazaki, Linzi Connor, Vivek Kumar, Ikuo Miura, Tomohiro Suzuki, Atsushi Watanabe, Manabu Abe, Fumihiro Sugiyama, Satoru Takahashi, Kenji Sakimura, Yu Hayashi, Qinghua Liu, Kazuhiko Kume, Shigeharu Wakana, Joseph S. Takahashi, Masashi Yanagisawa.
Forward-genetics analysis of sleep in randomly mutagenized mice.
Nature 539, 378-383 (2016).
*Introduced in the following News & Views:
Derk-Jan Dijk & Raphaëlle Winsky-Sommerer “Neuroscience: Sleepy and dreamless mutant mice,”
Nature 539, 364–365 (2016)
- 林 悠, 鹿糠 実香.
実験医学別冊 マウス表現型解析スタンダード－系統の選択、飼育環境、臓器・疾患別解析のフローチャートと実験例－（羊土社）.
第4章, 第10節「睡眠と覚醒の表現型解析」(2016).
- 柏木 光昭, 高木 眞莉奈, 安垣 進之助, 林 悠.
レム・ノンレム睡眠と覚醒の制御機構.
学会誌「時間生物学」22 (2), 61-64 (2016).
- 柏木 光昭, 林 悠.
夢を生じるレム睡眠やノンレム睡眠の記憶学習における役割.
生体の科学（医学書院）67 (1), 56-60 (2016).
- 林 悠, 柏木 光昭, 糸原 重美.
レム睡眠とノンレム睡眠との切り替えを司るニューロンの同定と操作により明らかとなったレム睡眠の意義.
実験医学（羊土社）34 (6), 943-945 (2016).
- 柏木 光昭, 高木 眞莉奈, 安垣 進之助, 林 悠.
レム・ノンレム睡眠と覚醒の制御機構.
BIO Clinica（北隆館）31, 921-925 (2016).
- 林 悠, 柏木 光昭, 糸原 重美.
レム睡眠とノンレム睡眠との切り替えを担うニューロンの同定により明らかにされたレム睡眠の役割.
ライフサイエンス新着論文レビュー, DOI: 10.7875/first.author.2015.132 (2015).
- Yu Hayashi, Mitsuaki Kashiwagi, Kosuke Yasuda, Reiko Ando, Mika Kanuka, Kazuya Sakai, Shigeyoshi Itohara.
Cells of a common developmental origin regulate REM/non-REM sleep and wakefulness in mice.
Science 350, 957-961 (2015) DOI: 10.1126/science.aad1023
*Introduced in the following Perspective:
Vladyslav V. Vyazovskiy “Mapping the birth of the sleep connectome,” Science 350, 909-910 （2015）
- Suzuki, A., Lee, L.J., Hayashi, Y., Muglia, L., Itohara, S., Erzurumlu, R.S., Iwasato, T.
Thalamic adenylyl cyclase 1 is required for barrel formation in the somatosensory cortex.
Neuroscience 290, 518-529 (2015).
- Arakawa, H., Suzuki, A., Zhao, S., Tsytsarev, V., Lo, F.S., Hayashi, Y., Itohara, S., Iwasato, T., Erzurumlu, R.
Thalamic NMDA receptor function is necessary for patterning of the thalamocortical somatosensory map and for sensorimotor behaviors.
Journal of Neuroscience 34, 12001-12014 (2014).
- 林 悠, 宮崎 慎一.
睡眠マネジメント―産業衛生・疾病との係わりから最新改善対策まで― (NTS).
第１章, 第８節「睡眠と脳機能」(2014).
- Hayashi, Y.
Transgenic animals (Review).
Brain Encyclopedia, DOI：10.14931/bsd (2013).
- 林 悠.
ニューロン同士をつなぐ神経突起の除去か維持かの決定におけるWnt-Ror経路の役割.
実験医学（羊土社）28 (1), 78–81 (2010).
- Hirotsu, T., Hayashi, Y., Iwata, R., Kunitomo, H., Kage-Nakadai, E., Kubo, T., Ishihara, T., Iino, Y.
Behavioural assay for olfactory plasticity in C. elegans.
Protocol Networks, DOI:10.1038/nprot.2009.139 (2009).
- Yu Hayashi, *Takaaki Hirotsu, (*Co-second author), *Ryo Iwata (*Co-second author), Eriko Kage-Nakadai, Hirofumi Kunitomo, Takeshi Ishihara, Yuichi Iino, Takeo Kubo.
A trophic role for Wnt-Ror kinase signaling during developmental pruning in Caenorhabditis elegans.
Nature Neuroscience 12, 981-987 (2009) DOI: 10.1038/nn.2347
- *Eriko Kage (*Co-first author), *Yu Hayashi (*Co-first author), Hideaki Takeuchi, Takaaki Hirotsu, Hirofumi Kunitomo, Takao Inoue, Hiroyuki Arai, Yuichi Iino, Takeo Kubo.
MBR-1, a novel helix-turn-helix transcription factor, is required for pruning excessive neurites in Caenorhabditis elegans.
Current Biology 15, 1554-1559 (2005) DOI: 10.1016/j.cub.2005.07.057