Department of Biological Sciences, Graduate School of Science, The University of Tokyo; International Institute for Integrative Sleep Medicine, University of Tsukuba (WPI-IIIS)
Publication
Taizo Kawano, Mitsuaki Kashiwagi, Mika Kanuka, Chung-Kuan Chen, Shinnosuke Yasugaki, Sena Hatori, Shinichi Miyazaki, Kaeko Tanaka, Hidetoshi Fujita, Toshiro Nakajima, Masashi Yanagisawa, Yoshimi Nakagawa, Yu Hayashi. ER proteostasis regulators cell-non-autonomously control sleep. Cell Reports42(3):112267 (2023). DOI:10.1016/j.celrep.2023.112267
Fangzhou Li, Shoya Matsumori, Naohiro Egawa, Shusuke Yoshimoto, Kotaro Yamashiro, Haruo Mizutani, Noriko Uchida, Atsuko Kokuryu, Akira Kuzuya, Ryosuke Kojima, Yu Hayashi, Ryosuke Takahashi. Predictive diagnostic approach to dementia and dementia subtypes using wireless and mobile electroencephalography-A pilot study. Bioelectricity Mar 2022.3-11. doi.org/10.1089/bioe.2021.0030
Yusuke Murakami, Minori Masaki, Shinichi Miyazaki, Ryosuke Oketani, Yu Hayashi, Masashi Yanagisawa, Sakiko Honjoh, and Hideaki Kano. Spectroscopic second and third harmonic generation microscopy using a femtosecond laser source in the third near-infrared (NIR-III) optical window. Biomedical Optics Express 13(2), 694-708(2022)
Hibiki Okamura, Shinnosuke Yasugaki, Haruka Suzuki-Abe, Yoshifumi Arai, Katsuyasu Sakurai, Masashi Yanagisawa, Hotaka Takizawa, and Yu Hayashi. Long-term effects of repeated social defeat stress on brain activity during social interaction in BALB/c mice. eNeuro 9(3) DOI:10.1523/ENEURO.0068-22.(2022)
Shinnosuke Yasugaki, Yu Hayashi, Michael Lazarus. NREM-REM sleep reguration. Reference Module in Neuroscience and Biobehavioral Psychology DOI: 10.1016/B978-0-12-822963-7.00229-2 (2021)
和泉 賢明、林 直子、高橋 良輔、林 悠 睡眠・覚醒の調節機構：その謎から臨床へ 睡眠の進化：無脊椎動物から脊椎動物に至る多様な生物の眠りから考える Progress in Medicine Vol.41 No.12:50-55 (2021)
Mitsuaki Kashiwagi, Mika Kanuka, Kaeko Tanaka, Masayo Fujita, Ayaka Nakai, Chika Tatsuzawa, Kazuto Kobayashi, Kazutaka Ikeda, Yu Hayashi. Impaired wakefulness and rapid eye movement sleep in dopamine-deficient mice. Molecular Brain 14:170 (2021).
Chia-Jung Tsai, Takeshi Nagata, Chih-Yao Liu, Takaya Suganuma, Takeshi Kanda, Takehiro Miyazaki, Kai Liu, Tsuyoshi Saitoh, Hiroshi Nagase, Michael Lazarus, Kaspar Vogt, Masashi Yanagisawa, Yu Hayashi. Cerebral capillary blood flow upsurge during REM sleep is mediated by A2A receptors. Cell Reports 17:109558 (2021).
Ayaka Nakai, Tomoyuki Fujiyama, Nanae Nagata, Mitsuaki Kashiwagi, Aya Ikkyu, Marina Takagi, Chika Tatsuzawa, Kaeko Tanaka, Miyo Kakizaki, Mika Kanuka, Taizo Kawano, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Takeshi Sakurai, Masashi Yanagisawa, Yu Hayashi. Sleep Architecture in Mice Is Shaped by the Transcription Factor AP-2β. Genetics 216:753-764 (2020). *Selected for the 2020 Spotlight collection of research and scholarship excellence published in the GSA journals
Risa Yamazaki, Hirofumi Toda, Paul-Antoine Libourel, Yu Hayashi, Kaspar E Vogt, and Takeshi Sakurai. Evolutionary Origin of Distinct NREM and REM Sleep. Frontiers in Psychology 11:567618 (2020).
Michael Lazarus, Yu Hayashi, Sakiko Honjoh, Kaspar E Vogt, Ada Eban-Rothschild, Qinghua Liu, and Takeshi Sakurai. Editorial: The Gating and Maintenance of Sleep and Wake: New Circuits and Insights. Frontiers in Neuroscience 14:773 (2020).
Shinichi Miyazaki, Philippe Leproux, Vincent Couderc, Yu Hayashi, Hideaki Kano. Multimodal nonlinear optical imaging of Caenorhabditis elegans with multiplex coherent anti-Stokes Raman scattering, third-harmonic generation, second-harmonic generation, and two-photon excitation fluorescence. Applied Physics Express 13:072002-1-5 (2020).
Mitsuaki Kashiwagi and Yu Hayashi. The existence of two states of sleep as a common trait in various animals and its molecular and neuronal mechanisms. Current Opinion in Physiology 15: 197-202 (2020).
Chih-Yao Liu, Chia-Jung Tsai, Shinnosuke Yasugaki, Nanae Nagata, Miho Morita, Ayako Isotani, Masashi Yanagisawa and Yu Hayashi. Copine-7 is required for REM sleep regulation following cage change or water immersion and restraint stress in mice. Neuroscience Research 165:14-25 (2020).
Sakura Eri B. Maezono (*Co-first author), Mika Kanuka (*Co-first author), Chika Tatsuzawa, Miho Morita, Taizo Kawano, Mitsuaki Kashiwagi, Pimpimon Nondhalee, Masanori Sakaguchi, Takashi Saito, Takaomi C. Saido, Yu Hayashi. Progressive changes in sleep and its relations to amyloid-β distribution and learning in single App knock-in mice. eNeuro 7(2) ENEURO.0093-20.2020 1–14 (2020).
Chia-Jung Tsai, Chih-Yao Liu, Michael Lazarus, Yu Hayashi. Sleep architecture of adenosine A2A receptor-deficient mice. Sleep and Biological Rhythms 18:275-279 (2020).
Mitsuaki Kashiwagi, Mika Kanuka, Chika Tatsuzawa, Hitomi Suzuki, Miho Morita, Kaeko Tanaka, Taizo Kawano, Jay W Shin, Harukazu Suzuki, Shigeyoshi Itohara, Masashi Yanagisawa, Yu Hayashi. Widely Distributed Neurotensinergic Neurons in the Brainstem Regulate NREM Sleep in Mice. Current Biology 30:1002 (2020).
Shinnosuke Yasugaki, Chih-Yao Liu, Mitsuaki Kashiwagi, Mika Kanuka, Takato Honda, Shingo Miyata, Masashi Yanagisawa, Yu Hayashi. Effects of 3 Weeks of Water Immersion and Restraint Stress on Sleep in Mice. Frontiers in Neuroscience 13:1072 (2019).
Mitsuaki Kashiwagi and Yu Hayashi. Life Without Dreams: Muscarinic Receptors Are Required to Regulate REM Sleep in Mice. Cell Reports 24, 2211-2212 (2018).
Shinichi Miyazaki, Chih-Yao Liu, and Yu Hayashi. Sleep in vertebrate and invertebrate animals, and insights into the function and evolution of sleep. Neuroscience Research 118, 3-12 (2017).
Yu Hayashi and Shigeyoshi Itohara. Cutting-edge approaches to unwrapping the mysteries of sleep. Neuroscience Research 118, 1-2 (2017).
Yasuda, K., Hayashi, Y., Yoshida, T., Kashiwagi, M., Nakagawa, N., Michikawa, T., Tanaka, M., Ando, R., Huang, A., Hosoya, T., McHugh, T.J., Kuwahara, M., Itohara, S. Schizophrenia-like phenotypes in mice with NMDA receptor ablation in intralaminar thalamic nucleus cells and gene therapy-based reversal in adults. Translational Psychiatry 7, e1047 (2017).
Yu Hayashi and Chih-Yao Liu. Brain Evolution by Design: From Neural Origin to Cognitive Architecture. Springer; 1st ed. Chapter 15. The Evolution and Function of Sleep (2017).
Hayashi, Y. (†Co-corresponding author), Kashiwagi, M., Yasuda, K., Ando, R., Kanuka, M., Sakai, K., Itohara, S (†Co-corresponding author). Cells of a common developmental origin regulate REM/non-REM sleep and wakefulness in mice. Science 350, 957-961 (2015). *Introduced in the following Perspective: Vladyslav V. Vyazovskiy “Mapping the birth of the sleep connectome,” Science 350, 909-910 （2015）
Suzuki, A., Lee, L.J., Hayashi, Y., Muglia, L., Itohara, S., Erzurumlu, R.S., Iwasato, T. Thalamic adenylyl cyclase 1 is required for barrel formation in the somatosensory cortex. Neuroscience 290, 518-529 (2015).
Arakawa, H., Suzuki, A., Zhao, S., Tsytsarev, V., Lo, F.S., Hayashi, Y., Itohara, S., Iwasato, T., Erzurumlu, R. Thalamic NMDA receptor function is necessary for patterning of the thalamocortical somatosensory map and for sensorimotor behaviors. Journal of Neuroscience 34, 12001-12014 (2014).
Hirotsu, T., Hayashi, Y., Iwata, R., Kunitomo, H., Kage-Nakadai, E., Kubo, T., Ishihara, T., Iino, Y. Behavioural assay for olfactory plasticity in C. elegans. Protocol Networks, DOI:10.1038/nprot.2009.139 (2009).
Hayashi, Y. (†Corresponding author), Hirotsu, T. (*Co-second author), Iwata, R. (*Co-second author), Kage-Nakadai, E., Kunitomo, H., Ishihara, T., Iino, Y., Kubo, T. A trophic role for Wnt-Ror kinase signaling during developmental pruning in Caenorhabditis elegans. Nature Neuroscience 12, 981-987 (2009).
*Kage, E. (*Co-first author), *Hayashi, Y. (*Co-first author), Takeuchi, H., Hirotsu, T., Kunitomo, H, Inoue, T., Arai, H., Iino, Y., Kubo, T. MBR-1, a novel helix-turn-helix transcription factor, is required for pruning excessive neurites in Caenorhabditis elegans. Current Biology 15, 1554-1559 (2005).